A licensed clinical psychologist in the U.S. and Europe, professor at the Catholic University in Milan, and an entrepreneur, Dr. Wiederhold is the CEO of the Virtual Reality Medical Institute in Belgium and the Executive Vice-President of the Virtual Reality Medical Center in California. She completed the first randomized, controlled clinical trial to provide virtual reality medical therapy for war veterans suffering from posttraumatic stress disorder (PTSD). Her most recent achievement is working with coalition troops to provide stress inoculation training prior to deployment.

These are in addition to her VR work since the mid-1990s with the civilian sector of patients. She works to inform and educate policymakers, funding agents, and both the scientific community and general public to advance the medical field with technology. Dr. Wiederhold is recognized as a world leader in the treatment of anxiety, panic, phobias, and PTSD with VR exposure and cognitive-behavioural therapy, objectively measuring results with physiological monitoring devices. She is the founder of the international CyberPsychology & CyberTherapy Conference, now in its 18th year, and the Editor-in-Chief of the MedLine-indexed CyberPsychology, Behavior, & Social Networking Journal. She has given invited lectures on the topic of advanced technologies and healthcare in 24 countries throughout Europe and Asia and has published more than 150 articles and twelve books on the subject.